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APIRON®

Water soluble
APIRON®
Active substance —

water-soluble powder for oral administration

Description

Powder, white-coloured.

Composition

1 g of the drug contains:

active ingredient - acetylsalicylic acid – 400 mg.

Excipient: glucose.

water-soluble powder for oral administration

Description

Powder, white-coloured.

Composition

1 g of the drug contains:

active ingredient - acetylsalicylic acid – 400 mg.

Excipient: glucose.

Pharmacological properties

ATC vet index QN02 - drugs for nervous system. Analgesics. QN02ВA01 - Acetylsalicylic acid.

Acetylsalicylic acid is an antipyretic, anti-inflammatory, analgesic, antiaggregant agent, which is a derivative of salicylic acid.

Anti-inflammatory effect of acetylsalicylic acid is caused by impact upon processes taking place at the site of inflammation: it reduces capillary permeability, decreases the activity of hyaluronidase, restricts energetic support of inflammatory process through inhibition of ATP formation etc. The main mechanism of action of acetylsalicylic acid is the inactivation of the enzyme COX (cyclooxygenase), resulting in reduced production of inflammatory mediators:prostaglandins, prostacyclin and thromboxane. Decreased prostaglandin synthesis leads to a decrease in their effect on the centers of thermoregulation, which leads to a decrease in temperature due to inflammation. It reduces the sensitizing effect of prostaglandins on pain-sensitive nerve endings, reduces their sensitivity to pain mediators. Analgesic effect is caused with impact upon pain sensitivity centers as well as capability to reduce algogenic effect of bradykinin. Irreversible inhibition of thromboxane A2 synthesis in platelets causes the antiplatelet effect of acetylsalicylic acid.

After oral administration, acetylsalicylic acid is rapidly and completely absorbed from the digestive tract. It is rapidly metabolized to salicylic acid, the half-life is 15-30 minutes. Salicylic acid is metabolized mainly in the liver. Metabolites of salicylic acid are glycine, glucuronic acid conjugates and traces of gentisic acid. Salicylic acid and its metabolites are excreted mainly by the kidneys.

Administration

Symptomatic treatment of calves (under 3 months of age), pigs and poultry (broiler chickens, repair young poultry) in pathological conditions accompanied by hyperthermia, inflammatory and pain syndromes of low and medium intensity of various genesis (including inflammatory), including fever, respiratory and digestive tract diseases, MMA syndrome (metritis-mastitis-agalactia), rheumatoid arthritis, osteoarthritis, muscle and postoperative pain, heat stress.

Dosage

Orally with drinking water or feed in the following doses:

calves (under 3 months old) - 40 mg of acetylsalicylic acid per 1 kg of body weight (100 mg of the drug per 1 kg of body weight) a day;

swine - 40 mg of acetylsalicylic acid per 1 kg of body weight (100 mg of the drug per 1 kg of body weight) a day;

poultry (broiler chickens, pullets) - 40 mg of acetylsalicylic acid per 1 kg of body weight (100 mg of the drug per 1 kg of body weight) a day or 15-30 g of the drug per 100 l of drinking water a day.

It is administered with an interval of 24 hours, a course of treatment of 3 - 5 days.

 Contraindications

Do not administer in animals with hypersensitivity to acetylsalicylic acid and other non-steroidal anti-inflammatory drugs.

Do not administer in animals with dehydration, chronic diseases of the digestive tract, with impaired blood clotting.

Do not use when using anticoagulants, as well as two weeks before the planned operation.

Do not administer in lactating animals and do not use in laying hens whose eggs are used for human consumption.

Do not administer in piglets under 1 month old, pregnant and lactating sows.

Do not use with other non-steroidal anti-inflammatory drugs, glucocorticosteroids and aminoglycosides.

Precautions

Side effect

If the drug is administered in recommended doses, side effects do not appear.

Possible side effects of acetylsalicylic acid include:  irritation of the stomach and intestines, ulcers, digestive disorders, bronchospasm.

Special precautions for administration

During treatment, animals shall receive plenty of drinking water.

Surgery shall not be performed on animals for 7 days after stopping treatment, as the drug may interfere with blood clotting.

Excretion (withdrawal) period

Animal slaughter for meat is allowed in 1 day following the last drug administration. Meat, obtained before the mentioned term, shall be utilized or fed to non-productive animals depending on the statement of a veterinary physician.

Packaging

Packages made of film or foil materials of 100 g and 1 kg.

Storage

Store in a dry dark place out of the reach of children at 5-30 °С.

Shelf life - 3 years.

24 hours after dissolution in water.

For veterinary use only!