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BIONON®

powder for oral administration

Description

Light-brown powder.

Composition

1 g of the drug contains:

active ingredient: nosiheptide – 5 mg;

excipient - semolina.

Pharmacological properties

АТСvet: QA07A - Intestinal anti-infectives.

Nosiheptide is an antibiotic of the polypeptides group. It makes bactericidal effect upon gram-positive microorganisms (Clostridium perfringens, Streptococcus spp., Staphylococcus spp.), as well as certain gram-negative (Pasteurella multocida, Neisseria catarrhalis). Nosiheptide makes effect upon bacterial synthesis of proteins, that is – upon 50S ribosomal subunits, and tightly binds the 23S-rRNA complex to the ribosomal protein L11. It is not absorbed from the digestive tract, therefore, it makes impact exclusively upon intestinal microflora. It inhibits growth of microorganisms producing ammonia, facilitating reduction of the ammonia level in digestive tract.

The resistance of bacteria to the active ingredient develops slowly. No resistance of Clostridium perfringens is observed. No cross-resistance with other antibacterial preparations is observed in microorganisms.

High concentration of nosiheptide formed in the digestive tract contributes to long-term antibacterial effect. It is not accumulated in body tissues and is excreted unchanged.

Administration

Treatment of cage birds (canaries, parrots, pigeons) in diseases of the digestive tract, including in necrotic enteritis caused by microorganisms sensitive to the active substance of the drug.

Dosage

Orally with feed in the following doses:

canaries, parrots, pigeons - 0.4-0.5 g of the drug per 1 kg of feed for 5-7 days. Feed with the drug shall be the only source of nutrition throughout the period of drug administration!

If necessary, the course of treatment can be repeated.

Contraindications

Do not administer in animals with hypersensitivity to drug components.

Do not use in productive animals!

Precautions

Bionon® is not prescribed in sub-therapeutic doses.

Packaging

Paper bags of 100 g.

Storage

Store in a dry, dark place out of the reach of children at 5-30 °С.

Shelf life

2 years.

For veterinary use only!