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ENROL® 10

ENROL® 10
Active substance —

solution for oral administration

Description

Transparent yellow solution.

Composition

1 ml of the drug contains:

active ingredient: enrofloxacin – 100 mg;

Excipients: potassium hydroxide, purified water.

solution for oral administration

Description

Transparent yellow solution.

Composition

1 ml of the drug contains:

active ingredient: enrofloxacin – 100 mg;

Excipients: potassium hydroxide, purified water.

Pharmacological properties

ATCvet: QJ01– antibacterials for systemic use. QJ01МA90 - Enrofloxacin.

Enrofloxacin is a broad-spectrum antibiotic of the fluoroquinolone group. It has antibacterial acction against gram-positive (Staphylococcus spp., Streptococcus spp., Clostridium spp., Listeria monocytogenes, Corynebacterium spp. etc.) and gram-negative microorganisms (Pseudomonas spp., E. coli, Haemophilus spp., Salmonella spp., Klebsiella spp., Proteus spp., Pasteurella spp. etc.), as well as mycoplasma (Mycoplasma spp.) and chlamydiae (Chlamidia spp.). Its mechanism of action is related to inhibition of bacterial DNA-gyrase, resulting in violation of DNA replication in microorganisms.

Enrofloxacin is quickly absorbed from digestive tract and well distributed in body tissues and fluids. Its maximum concentration in blood is reached already in 60-120 minutes, maintained for 6 hours, the therapeutic concentration is maintained for 24 hours. Practically not subject to biotransformation, partially metabolized to ciprofloxacin. Feed in the stomach does not affect drug absorption. Binding of enrofloxacin to proteins makes 24±2%. The highest enrofloxacin concentrations are observed in bile, kidneys, liver, lungs and reproductive organs. Enrofloxacin is primarily excreted renally. Metabolites are excreted in urine, bile and feces.

Administration

Treatment of broiler chickens in diseases of the respiratory and digestive tract caused by microorganisms sensitive to enrofloxacin.

Dosage

Orally with drinking water at a dose of 10 mg of enrofloxacin per 1 kg of body weight of broiler chickens or 0.5-1 ml of the drug per 1 l of drinking water. Duration of treatment –3-5 days;

Contraindications

Do not administer to animals with hypersensitivity to enrofloxacin.

Do not administer to hens, laying eggs for human consumption.

Do not administer in combination with drugs containing Mg2+, Al3+, Ca2+ cations, that may interfere with enrofloxacin absorption.

Do not use for prevention, as well as for resistant pathogen strains.

Do not administer in combination with tetracycline drugs, macrolides (erythromycin), chloramphenicol, theophylline and steroids.

Precautions

Special precautions for administration

During treatment, broiler chickens are given only water with the drug.

The dissolved drug shall be used within 24 hours.

Before treatment, it is recommended to determine the pathogen sensitivity to enrofloxacin.

Excretion (withdrawal) period

Slaughter of broiler chickens for meat is allowed in 11 days following the last drug administration. Meat, obtained before the mentioned term, shall be utilized or fed to non-productive animals depending on the statement of a veterinary physician.

Special precautions

If the mother solution is prepared, the drug shall be added in water. Medicated water shall be the only source of drinking water throughout the whole treatment period! The drug is not prescribed in sub-therapeutic doses.

Packaging

Vials of 1, 2, 10, 50, 100, 200, 500 ml and 1 l or containers of 4, 5, 10, 25 and 50 l.

Storage

Store in a dry, dark place out of the reach of children at 5-30 °С.

Shelf life - 3 years.

Shelf life is 24 hours after dissolution in drinking water.

For veterinary use only!