FARMAST®

suspension for intracisternal administration

Description

Viscous opaque yellow suspension with specific odor.

Composition

1 syringe tube (10 ml) contains:

active ingredients: amoxicillin (amoxicillin trihydrate) - 670 mg; gentamicin (gentamicin sulfate) - 75 mg;  prednisolone - 10 mg;.

excipient - vegetable oil.

Pharmacological properties

Amoxicillin is a broad-spectrum bactericidal antibiotic of the penicillin group. It is effective against gram-positive (Staphylococcus spp. strains, not producing penicillinase, Clostridium spp., Arcanobacterium spp., Bacillus anthracis, Listeria monocytogenes, Erysipelothrix rhusiopathiae) and gram-negative microorganisms (Pasteurella spp., Mannheimia haemolytica, Haemophillus spp., Actinobacillus spp., Escherichia coli, Salmonella spp., Moraxella spp. and Fusobacterium spp.). Amoxicillin inhibits mucopeptide synthesis – one of the bacterial cell wall components, ensuring mechanical stability of microorganism, and thereby destroys bacteria in its growth stage.

Gentamicin belongs to aminoglycoside antibiotics. It provides bactericidal effect against gram-negative microorganisms such as: Enterobacter aerogenes, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Salmonella spp. and Shigella spp. Gentamicin is also effective against such gram-positive bacteria as: Treponema hyodysenteriae, Staphylococcus aureus and β-hemolytic Streptococcus. It makes direct effect upon ribosomes, where it inhibits biosynthesis of proteins and decreases accuracy of genetic code translation. Penetration of gentamicin into bacterial cell intensifies as its wall permeability increases under amoxicillin effect. This synergism makes it possible to use less aminoglycosides.

Prednisolone is a dehydrogenated analogue of hydrocortisone. It has the properties inherent to other compounds of this group, that is:  anti-inflammatory, desensitizing, anti-allergenic, antishock and anti-toxic. By stimulation of steroid receptors, the drug induces formation of special protein class - lipoproteins, providing antiedemic activity, as well as reduces hyaluronidase activity and permeability of capillaries.

The combination of amoxicillin and gentamicin creates a broad antibacterial range upon gram-positive (primarily streptococci, staphylococci and Corynebacterium) and gram-negative microorganisms (particularly, Escherichia coli, Pasteurella spp., Salmonella spp. and Pseudomonas spp.). This combination improves therapeutic properties of each of these separately administered antibiotics.

Administration

Farmast® is used to treat clinical and subclinical bacterial mastitis caused by microorganisms sensitive to the drug components in cattle.

Dosage

Administer the contents of a single syringe tube (10 ml),  heated to body temperature into the teat canal of the injured quarter of the milked dry mammary gland once a day  until complete clinical recovery (1-4 days).

Contraindications

Do not administer in animals with hypersensitivity to the drug components.

Precautions

Milk consumption and animal slaughter for meat is possible in 7 days following the last administration of the drug. Milk and meat, obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of a veterinary physician.

Packaging

Plastic 10 ml syringe tubes, 20 pcs. in package.

Storage

Store in original packaging in a dry, dark place out of the reach of children at 5–30 °С.

Shelf life

18 months.

For use in veterinary medicine!