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FORACOL®

FORACOL®

Description

White powder.

Composition

1 g of the drug contains:

ciprofloxacin hydrochloride – 200 mg;

trimethoprim – 100 mg;

colistin – 2.4 m IU;

Excipient: dextrose.

Description

White powder.

Composition

1 g of the drug contains:

ciprofloxacin hydrochloride – 200 mg;

trimethoprim – 100 mg;

colistin – 2.4 m IU;

Excipient: dextrose.

Pharmacological properties

АТСvet: QJ01 - antibacterials for systemic use.

The drug contains combination of ciprofloxacin, trimethoprim and colistin, which has a synergic antimicrobial effect.

Cyprofloxacin is a broad-spectrum antibiotic of the fluoroquinolone group. It demonstrates antimicrobial effect upon gram-positive and gram-negative microorganisms (Staphylococcus spp., Streptococcus spp., Clostridium spp., Listeria monocytogenes, Corynebacterium spp., Pseudomonas spp., E. coli, Haemophilus spp., Salmonella spp., Klebsiella spp., Proteus spp., Pasteurella spp., etc.), as mycoplasma (Mycoplasma spp.) and chlamydiae (Chlamydia spp.). The mechanism of action of ciprofloxacin is related to inhibition of bacterial DNA-gyrase, resulting in violation of DNA replication in microorganisms.

Trimethoprim is a broad-spectrum antibacterial of the diaminopiryrimidine group. It is effective against gram-positive and gram-negative microorganisms (E. coli, Klebsiella spp., Salmonella spp., Pasteurella spp., Enterobacter spp., Proteus spp., Shigella spp., Staphylococcus spp., Streptococcus spp., Haemophilus spp., Chlamydia spp.), as well as toxoplasma and coccidia. The mechanism of action of trimethoprim consists in inhibition of bacterial reductase of dihydrofolic acid.

Colistin is an antibiotic of the polymyxin group, which demonstrates bactericidal effect against gram-negative microorganisms (E. сolі, Salmonella spp., Pasteurella spp., Haemophіlus spp., Bordetella spp.). The mechanism of action of colistin consists in violation of integrity of cytoplasmic membrane in bacteria. The antibiotic interacts with phospholipids and penetrates inside, destroying structure of cell membrane, its permeability changes immediately upon contact with the drug. Apart from antibacterial effect, colistin binds phospholipid А and neutralizes biological effect of bacterial endotoxin.

Ciprofloxacin is quickly absorbed from digestive tract and well distributed in body tissues and fluids. Maximum drug concentration in blood is reached already in 60-120 minutes. The feed in the stomach does not make any impact upon the drug absorption. Binding of ciprofloxacin to proteins makes 24%±2%. Its highest concentrations are observed in bile, kidneys, liver, lungs, reproductive organs. Ciprofloxacin is primarily excreted renally. Metabolites are excreted with in and feces.

Trimethoprim is metabolized in liver and is primarily excreted renally through glomerular filtration and active tubular secretion. Its concentration in urine is essentially higher than in blood. Half-life period makes 8-10 hours.

After oral administration colistin is poorly absorbed from digestive tract. In contrast to low concentrations of colistin in blood serum and tissues, its concentration in various segments of digestive tract is constantly high. Colistin is eliminated from the body with feces.

Administration

Treatment of poultry against colibacteriosis, salmonellosis, necrotic enteritis, streptococcus, haemophillosis, mycoplasmosis and other infectious diseases caused by ciprofloxacin-, trimethoprim- and colistin-sensitive microorganisms.

Dosage

Administer orally with drinking water in a dose of 0.5 g per 1 l of drinking water (500 g per 1 t of drinking water) for 4-6 days.

In case the drug is given through dispenser, prepare the stock solution at the ratio at least 15 parts of water per 1 part of the drug. Medicated water shall be the only source of drinking water throughout the whole treatment period!

Contraindications

Do not prescribe to animals sensitive to the drug components.

Do not administer to animals with impaired renal and/or hepatic function.

Do not administer in combination with antibiotics of the tetracycline group, chloramphenicol, lincomycin.

Do not administer to productive animals and poultry!

Precautions

Medicated solution shall be the only source of drinking water throughout the whole treatment period.

Do not prescribe the drug in sub-therapeutic doses and animals with hypersensitivity to the drug components.

Packaging

Polymer or glass jars, bags made of film or foil materials of 100 g

Storage

Store in a dry, dark place out of the reach of children at 5-30°С.

Shelf life

3 years.

24 hours after dissolution in drinking water.

For use in veterinary medicine!