water-soluble powder for oral administration
150 g of the drug contains:
lincomycin hydrochloride – 33.3 g; spectinomycin sulfate – 66.7 g;
ATCvet: QJ01— antibacterials for systemic use. QJ01FF52 - Lincomycin, combinations.
Spelimix® 100 is a complex drug, containing lincomycin and spectinomycin. The drug has a wide range of antibacterial action. The combination of lincomycin and spectinomycin has a potentiating effect on bacteria.
Lincomycin is a lincosamide antibiotic. It inhibits protein synthesis in microorganisms, binding ribosomal 50S subunits of bacterial cells. It has a bacteriostatic or bactericidal effect, depending on the concentration. It acts primarily against gram-positive (Staphylococcus spp., Streptococcus spp., Bacillus anthracis, Corynebacterium spp.) and gram-negative (Actinobacillus spp., Bordetella spp., Nocardis spp., Actinomyces spp.) microorganisms. It is particularly effective against Serpulina hyodysenteriae and Mycoplasma spp.
Spectinomycin is a tricyclic structure antibiotic of aminoglycosides. The efficiency of action consists in inhibition of protein synthesis in microbial cell by binding 30S ribosomal subgroups of microorganisms to prevent polypeptide chain prolongation at the translocation stage. It acts primarily against gram-negative and gram-positive microorganisms (E. coli, Pasteurella multocida, Salmonella spp., Clostridium spp., Erysipelothrix rhusiopathiae, Haemophilus spp., Vibrio spp.), as well as mycoplasma (Mycoplasma spp.).
After oral administration, lincomycin is well absorbed from digestive tract (almost 60%) and distributed in organs and tissues, including the bone tissue. Lincomycin binds with proteins up to 50%. Lincomycin concentration in serum reaches its maximum in 2 after administration. Its half-life makes 2.5-4 hours. Most of lincomycin and its metabolites are primarily excreted in urine and bile. Small amounts are excreted in feces.
Spectinomycin is poorly absorbed in digestive tract. In 24 hours following oral administration minor concentrations of the antibiotic are observed in kidneys, liver, lungs, muscles and fat tissue. Spectinomycin binding to proteins does not exceed 10%. Its concentration in blood serum reaches maximum in 4 hours. Spectinomycin is scarcely biotransformed in the body and is excreted unchanged in feces.
Treatment of hens (broiler chickens, brood hens, pullets) and swine against enzootic pneumonia, salmonellosis, dysentery, MMA (mastitis-metritis-agalactia) syndrome, necrotic enteritis, colibacillosis, mycoplasmosis and other diseases of digestive tract and respiratory organs caused by lincomycin- and spectinomycin-sensitive microorganisms.
Orally with drinking water in the following doses:
- piglets: 10 mg of the drug per 1 kg body weight one a day (1.5 g of powder per 100 kg body weight) or 150 g of the drug per 1500 l of drinking water. Duration of treatment: 4-7 days;
- Broiler chickens, brood hens, pullets: 150 g of the drug per 150-200 l of drinking water for 5-7 days.
The drug solution shall be the only source of drinking water throughout the whole treatment period!
Do not administer to animals with hypersensitivity to lincomycin and spectinomycin. Do not administer to hens, laying eggs for human consumption.
Do not use in combination with erythromycin.
Do not administer to pregnant animals.
In some cases, redness of the skin and mucous membranes may occur in swine after drug administration, it does not require drug withdrawal.
Special precautions for administration
Do not prescribe the drug in sub-therapeutic doses and animals with hypersensitivity to the drug components.
The dissolved drug shall be used within 24 hours.
Excretion (withdrawal) period
Animal and poultry slaughter for meat is allowed in 3 days (swine) and 2 days (broiler chickens, pullets and brood hens) following the last drug administration. Meat, obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of a veterinary physician.
Polymer or glass jars of 100 and 500g, 1 kg.
Packages made of film or foil materials of 1, 10, 50, 100 and 500 g, 1 kg.
Paper bags of 5, 10, 15 and 25 kg.
Store in a dry dark place out of the reach of children at 0-25 °С.
Shelf life is 24 hours after dissolution in drinking water.
For veterinary use only!