SPELMIX® 44

powder for oral administration

Description

White or yellowish powder.

Composition

1 g of the drug contains:

active ingredients: lincomycin hydrochloride – 22 mg; spectinomycin sulfate – 22 mg;

excipient - semolina.

Pharmacological properties

ATCvet: QJ01— antibacterials for systemic use. QJ01FF52 - Lincomycin, combinations.

Spelimix® 44 is a complex drug, containing lincomycin and spectinomycin. The drug has a wide range of antibacterial action. The combination of lincomycin and spectinomycin has a potentiating effect on bacteria.

Lincomycin is a lincosamide antibiotic. It inhibits protein synthesis in microorganisms, binding ribosomal 50S subunits of bacterial cells. It has a bacteriostatic or bactericidal effect, depending on the concentration. It acts primarily against gram-positive (Staphylococcus spp., Streptococcus spp., Bacillus anthracis, Corynebacterium spp.) and gram-negative (Actinobacillus spp., Bordetella spp., Nocardis spp., Actinomyces spp.) microorganisms. It is particularly effective against Serpulina hyodysenteriae and Mycoplasma spp.

Spectinomycin is a tricyclic structure antibiotic of aminoglycosides. The efficiency of action consists in inhibition of protein synthesis in microbial cell by binding 30S ribosomal subgroups of microorganisms to prevent polypeptide chain prolongation at the translocation stage. It acts primarily against gram-negative and gram-positive microorganisms (E. coli, Pasteurella multocida, Salmonella spp., Clostridium spp., Erysipelothrix rhusiopathiae, Haemophilus spp., Vibrio spp.), as well as mycoplasma (Mycoplasma spp.).

After oral administration, lincomycin is well absorbed from digestive tract (almost 60%) and distributed in organs and tissues, including the bone tissue. Lincomycin binds with proteins up to 50%. Lincomycin concentration in serum reaches its maximum in 2 after administration. Its half-life makes 2.5-4 hours. Most of lincomycin and its metabolites are primarily excreted in urine and bile. Small amounts are excreted in feces.

Spectinomycin is poorly absorbed in digestive tract. In 24 hours following oral administration minor concentrations of the antibiotic are observed in kidneys, liver, lungs, muscles and fat tissue. Spectinomycin binding to proteins does not exceed 10%. Its concentration in blood serum reaches maximum in 4 hours. Spectinomycin is scarcely biotransformed in the body and is excreted unchanged in feces.

Administration

Treatment of hens (broiler chickens, brood hens, pullets) and swine against enzootic pneumonia, salmonellosis, dysentery, MMA (mastitis-metritis-agalactia) syndrome, necrotic enteritis, colibacillosis, mycoplasmosis and other diseases of digestive tract and respiratory organs caused by lincomycin- and spectinomycin-sensitive microorganisms.

Dosage

Administer orally with feed individually to every animal or by group method in the following doses:

• swine - 2 kg of the drug per 1 t of feed for 5-7 days;
• broiler chickens, brood hens, pullets - 2 kg of the drug per 1 t of feed for 5-7 days.

If necessary, the duration of treatment shall be prolonged to 10 days.

Contraindications

Do not administer to animals with hypersensitivity to lincomycin and spectinomycin. Do not administer to hens, laying eggs for human consumption.

Do not administer in combination with erythromycin.

Do not administer in combination with drugs containing kaolin, Mg2+, Al3+, Ca2+ cations, that may interfere with drug absorption in the digestive tract.

Precautions

Side effect

In some cases, redness of the skin and mucous membranes may occur in swine after drug administration, it does not require drug withdrawal.

Special precautions for administration

Do not prescribe the drug in sub-therapeutic doses and animals with hypersensitivity to the drug components.

It is recommended to mix the drug with 3-10 % of the total feed first, then mix the resulting mixture with the remaining feed.

Excretion (withdrawal) period

Animal and poultry slaughter for meat is allowed in 3 days (swine) and 2 days (broiler chickens, pullets and brood hens) following the last drug administration. Meat, obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of a veterinary physician.

Packaging

Polymer or glass jars of 100 and 500g, 1 kg.

Packages made of film or foil materials of 1, 10, 50, 100 and 500 g, 1 kg.

Paper bags of 5, 10, 15 and 25 kg.

Storage

Store in a dry, dark place out of the reach of children at 0-25 °С.

Shelf life

1 year.

For veterinary use only!