SUPRIM® 240

solution for injections

Description

Transparent oily yellowish liquid.

Composition

1 ml of the drug contains:

active ingredients: sulfametoxazole – 200 mg; trimethoprim – 40 mg;

Excipient: propylene glycol, water for injections.

Pharmacological properties

ATCvet: QJ01— antibacterials for systemic use. QJ01EW11 - sulfamethoxazole and trimethoprim.

A combination of sulfamethoxazole and trimethoprim with synergistic action.

Sulfametoxazole is a medium-acting sulfanilamide. It breaks growth factors for microorganisms– folic acid and other substances, the molecules, containing para-aminobenzoic acid. In the microbial cell, sulfamethoxazole blocks formation of methionine, purine and pyrimidine bases that, resulting in impaired synthesis of nucleic acids and nucleoproteins. Sulfamethoxazole has a bacteriostatic effect on gram-positive (Staphylococcus spp.) and gram-negative (Neisseria spp., Heamophilus influenza, Escherichia coli. Proteus spp., Salmonella spp., Shigella spp.) microorganisms, and also acts against chlamydiae, nocardia, pneumocysts, actinomycetes, malarial plasmodia, toxoplasma.

Trimethoprim is a broad-spectrum antimicrobial product of diaminopyrimidine group, its mode of action is associated with inhibition of bacterial reductase of dihydrofolic acid. It has antibacterial action against gram-positive and gram-negative microorganisms (E. coli, Klebsiella spp., Salmonella spp., Pasteurella spp., Enterobacter spp., Proteus spp., Shigella spp., Staphylococcus spp., Streptococcus spp., Haemophilus spp., Chlamydia spp.), as well as toxoplasma and coccidia.

The mechanism of sulfamethoxazole and trimethoprim action is to inhibit the chain of paraaminobenzoic acid conversion to folic and then to tetrahydrofolic acid, required for the development of microbial cells. After a single injection, the drug components are well absorbed from the injection site and rapidly penetrate all organs and tissues, providing high therapeutic concentrations for up to 24 hours. The drug bioavailability by parenteral administration is 100%. Sulfamethoxazole is distributed primarily in the extracellular space, and trimethoprim - in body fluids. The drug passes through the blood-brain barrier weakly and is excreted in breast milk. It is metabolized in the liver, forming inactive metabolites, average half-life is 10 hours for both components. The drug is primarily excreted by kidneys, partially in bile, with renal failure it may accumulate drug components in the body.

Administration

Treatment of diseases of respiratory organs, digestive organs and urinary system caused by sulfametoxazole- and trimethoprim-sensitive microorganisms in cattle, sheep, goats, swine and rabbits.

Dosage

The drug is administered intramuscularly in the following doses:

• cattle (adult), sows: 1 ml of the drug per 20 kg body weight once a day for 3-5 days;
• calves, sheep, goats, piglets: 1 ml of the drug per 10 kg body weight once a day for 3-5 days;
• rabbits: 0.1 ml of the drug per 1 kg body weight once or twice with an interval of 1-1.5 days.

Contraindications

Hypersensitivity to trimethoprim and sulfametoxazole.

Do not administer in combination with sulfur-producing drugs (sodium sulfate), aminoglycosides (gentamicin, neomycin, streptomycin), as well as muscle relaxants and anesthetics as it may result in paralysis of respiratory muscles.

Do not use in combination with B vitamins due to possible antagonism.

Do not administer to animals with kidney and liver disorders as well as to animals with essential changes in hematological indices (in case of dyscrasia).

Do not use Novocain solution for dilution.

Precautions

Side effect

If the drug is administered in recommended doses, side effects do not appear.

Allergic reactions are rare. In case of allergic reactions, the drug is discontinued and antihistamines are prescribed to the animal; if necessary, administer symptomatic treatment.

Crystalluria (hematuria) may be observed after long-term drug administration in high doses. Withdraw the drug immediately and prescribe sodium hydrocarbonate (to increase sulfametoxazol solubility in urine).

Special precautions for administration

The drug shall be used only after results of the microorganisms susceptibility test.

Do not prescribe the drug in sub-therapeutic doses and animals with hypersensitivity to the drug components.

Administration in pregnancy and lactation

The drug in pregnant animals is recommended only when drug benefits outweigh the possible risks at the veterinarian's discretion.

Excretion (withdrawal) period

Animal slaughter for meat is possible in 12 days following the last administration of the drug.  Milk consumption is allowed in 4 days following the last drug administration. Meat and milk obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of a veterinary physician.

Packaging

Glass vials of 50 and 100 ml sealed with rubber stoppers and aluminum caps.

Storage

Store in a dry, dark place out of the reach of children at 5-30 °С.

Shelf life

2 years.

Use the drug within 48 hours following the initial withdrawal from the vial provided it is stored in a dry, dark place at 2-8  С.

For veterinary use only!