TRIFLON®

solution for oral administration

Description

Transparent yellow solution.

Composition

1 ml of the drug contains:

active ingredients: enrofloxacin – 100 mg;

trimethoprim – 50 mg;

Excipient: purified water.

Pharmacological properties

ATCvet: QJ01– antibacterials for systemic use. QJ01RA96 quinolones, combinations with other antibacterials

Enrofloxacin is a broad-spectrum antibiotic of the fluoroquinolone group. The drug has antibacterial action against gram-positive (Staphylococcus spp., Streptococcus spp., Clostridium spp., Listeria monocytogenes, Corinebacterium spp.) and gram-negative (Pseudomonas spp., E. coli, Haemophilus spp., Salmonella spp., Klebsiella spp., Proteus spp., Pasteurella spp., etc.) bacteria, as well as mycoplasma (Mycoplasma spp.) and chlamydiae (Chlamidia spp.). Its mechanism of action is related to inhibition of bacterial DNA-gyrase, resulting in violation of DNA replication in microorganisms.

Trimethoprim is a broad-spectrum antimicrobial product of diaminopyrimidine group. It is effective against gram-positive (Staphylococcus spp.; Streptococcus spp.) and gram-negative microorganisms (Escherichia coli, Klebsiella spp., Salmonella spp.; Pasteurella spp.; Enterobacter spp., Proteus spp.; Shigella spp.; Haemophilus spp.; Chlamidia spp.), as well as toxoplasma and coccidia. Its mode of action is associated with inhibition of bacterial reductase of dihydrofolic acid.

Enrofloxacin is quickly absorbed from digestive tract and well distributed in body tissues and fluids. Its maximum concentration in blood is reached already in 60-120 minutes. Feed in the stomach does not affect drug absorption. Binding of enrofloxacin to proteins makes 24±2%. Its highest concentrations are observed in bile, kidneys, liver, lungs and reproductive organs. Enrofloxacin is primarily excreted renally. Metabolites are excreted in urine and feces. Half-life period makes 24 hours.

Trimethoprim is quickly absorbed from digestive tract and well distributed in body tissues and fluids. Trimethoprim concentrations in tissues are generally higher than in the blood. High levels of Trimethoprim are present in lungs, kidneys and liver. Trimethoprim concentration in serum reaches its maximum in 1.5 after administration. Average half-life makes about 2.5 hours. Trimethoprim is primarily excreted renally. Trimethoprim concentration in urine is generally higher than in the blood. In poultry, the distribution volume of trimethoprim is 2.2 l/kg, bioavailability is 80%. Average half-life of trimethoprim in poultry makes 1-2 hours.

Administration

Treatment of colibacillosis, salmonellosis, necrotic enteritis, streptococcosis, hemophillosis, mycoplasmosis and other infectious diseases caused by enrofloxacin- and trimethoprim-sensitive microorganisms in broiler chickens.

Dosage

Administer orally with drinking water in a dose of 0.5-1 ml of the drug per 1 l of drinking water (or 10 mg enrofloxacin and 5 mg trimethoprim per 1 kg body weight) a day for 3-5 days. 

Contraindications

Hypersensitivity to enrofloxacin and trimethoprim.

Do not administer to hens, laying eggs for human consumption and pullets in 2 weeks prior to commencement of the laying period.

Do not administer in combination with non-steroid anti-inflammatory agents, antibiotics of the macrolides group, tetracycline and chloramphenicol.

Do not use for prevention, as well as for enrofloxacin resistant pathogen strains.

Precautions

Side effect

If the drug is administered in recommended doses, side effects do not appear.

Special precautions for administration

If the mother solution is prepared, the drug shall be added in water.

Medicated water shall be the only source of drinking water throughout the whole treatment period!

Excretion (withdrawal) period

Poultry slaughter for meat is possible in 11 days following the last administration of the drug. Meat, obtained before the mentioned term, shall be utilized or fed to non-productive animals depending on the statement of a veterinary physician.

Packaging

Glass or plastic vials of 10, 50, 100, 200, 500 and 1000 ml or plastic containers of 5, 10, 25 and 50 l.

Storage

Store in a dry, dark place out of the reach of children at 5-25 °С.

Shelf life - 3 years.

Shelf life is 24 hours after dissolution in drinking water.

For use in veterinary medicine!