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TRIMAST® FORTE

Intracesternal
TRIMAST® FORTE

solution for intramammary administration

Description

Colorless to light-yellow solution with specific odor of the components.

Composition

1 syringe tube (10 ml) contains

active ingredients: enrofloxacin – 200 mg;

trimethoprim – 100 mg;

prednisolone - 10 mg;

Excipients: purified water.

solution for intramammary administration

Description

Colorless to light-yellow solution with specific odor of the components.

Composition

1 syringe tube (10 ml) contains

active ingredients: enrofloxacin – 200 mg;

trimethoprim – 100 mg;

prednisolone - 10 mg;

Excipients: purified water.

Pharmacological properties

АТСvet: QJ51 - antibacterials for intramammary use. QJ51RV01 - antibacterials and corticosteroids.

Enrofloxacin is a broad-spectrum antibiotic of the fluoroquinolone group. The drug has antibacterial action on gram-positive and gram-negative bacteria (Staphylococcus spp., Streptococcus spp., Clostridium spp., Listeria monocytogenes, Corynebacterium spp., Pseudomonas spp., E. coli, Haemophilus spp., Salmonella spp., Klebsiella spp., Proteus spp., Pasteurella spp. etc.), as well as mycoplasma and chlamydiae. Its mechanism of action consists in inhibition of bacterial DNA-gyrase, resulting in violation of DNA replication in microorganisms. The drug is quickly distributed in organs and tissues. Therapeutic concentrations are reached in 1-1.5 hours following administration and are preserved for 24 hours.

Trimethoprim is a broad-spectrum antibacterial of the diaminopiryrimidine group. It is effective against gram-positive and gram-negative baccteria (Escherichia coli, Klebsiella spp., Salmonella spp., Pasteurella spp., Enterobacter spp., Proteus spp., Shigella spp., Staphylococcus spp., Streptococcus spp., Haemophilus spp., Chlamydia spp.), as well as toxoplasma and coccidia. The mechanism of action consists in inhibition of bacterial reductase of dihydrofolic acid.

Prednisolone is a corticosteroid with anti-inflammatory, antiallergenic, desensitizing and antiedemic action.

Administration

Treatment of clinical and subclinical forms of bacterial mastitis caused by microorganisms sensitive to the drug components in lactating cows.

Dosage

Heat the syringe tube on water bath before use to 35-38°С and shake intensely.

Administer the contents of a single syringe tube (10 ml), heated to body temperature into the teat canal of the injured quarter of the milked dry mammary gland twice a day.  Treat until complete clinical recovery (1-4 days).

Contraindications

Do not administer to animals with individual hypersensitivity to any active ingredient of the drug as they may cause allergic reactions.

Precautions

Consumption of milk is allowed in 3 days following the last drug administration. Milk, obtained before the mentioned term shall be fed to non-productive animals or utilized depending on a veterinary physician’s recommendation.

Packaging

Package with 20 polymer syringe tubes of 10 ml each.

Storage

Store in a dry, dark place out of the reach of children at 10-25 °С.

Shelf life

2 years.

For use in veterinary medicine!