TRIMICOSIN®

solution for oral administration

Description

Transparent yellow solution.

Composition

1 ml of the drug contains:

active ingredients: tilmicosin – 50 mg;

enrofloxacin – 50 mg;

trimethoprim – 25 mg;

Excipient: purified water.

Pharmacological properties

АТСvet: QJ01 - antibacterials for systemic use. QJ01RA96 quinolones, combinations with other antibacterials

The drug contains combination of enrofloxacin, tilmicosin and trimethoprim with synergistic antibacterial action.

Enrofloxacin is a broad-spectrum antibiotic of the fluoroquinolones group, with activity against gram-positive and gram-negative microorganisms (Staphylococcus spp., Streptococcus spp., Clostridium spp., Listeria monocytogenes, Corynebacterium spp., Pseudomonas aeruginosa, E. coli, Haemophilus spp., Salmonella spp., Klebsiella spp., Proteus spp., Pasteurella spp. та ін.), а as well as mycoplasma (Mycoplasma spp.) and chlamydiae (Chlamydia spp.). Its mechanism of action is related to inhibition of bacterial DNA-gyrase, resulting in violation of DNA replication in microorganisms.

Trimethoprim is a broad-spectrum antibacterial of the diaminopyrimidines group. It is effective against gram-positive and gram-negative microorganisms (E. coli, Klebsiella spp., Salmonella spp., Pasteurella spp., Enterobacter spp., Proteus spp., Shigella spp., Staphylococcus spp., Streptococcus spp., Haemophilus spp., Chlamydia spp.), as well as toxoplasma and coccidia. The mechanism of action consists in inhibition of bacterial reductase of dihydrofolic acid.

Tilmicosin is a broad-spectrum antibiotic of the macrolides group, it is effective against pathogens of respiratory diseases (M. gallisepticum, M. synoviae, P. multocida і Ornithobacterium rhinotracheale). Tilmicosin inhibits protein synthesis in microorganisms, interacting with ribosomes of bacterial cells.

Enrofloxacin is quickly absorbed from digestive tract and well distributed in body tissues and fluids. Its maximum concentration in blood is reached already in 60-120 minutes. Feed in the stomach does not affect enrofloxacin absorption. Binding of Enrofloxacin to proteins makes 24%±2%. Its highest concentrations are observed in bile, kidneys, liver, lungs and reproductive organs. Enrofloxacin is primarily excreted renally. Metabolites are excreted in urine and feces.

Trimethoprim is metabolized in liver and is primarily excreted renally through glomerular filtration and active tubular secretion. Trimethoprim concentration in urine is much higher than in blood. Half-life period makes 8-10 hours.

Tilmicosin is well absorbed from digestive tract. It accumulates in respiratory organs and macrophages in poultry in concentrations, considerably exceeding the concentration in blood serum. It is preserved in respiratory organs and tissues in therapeutic concentrations for over 2.5 days. It is metabolized with formation of several metabolites with antibacterial activity. It is primarily excreted in feces.

Administration

Treatment of mycoplasmosis, ornithobacteriosis, colibacillosis, salmonellosis, necrotic enteritis, streptococcosis as well as other diseases of digestive tract and respiratory organs caused by enrofloxacin-, tilmicosin- and timetoprim-sensitive microorganisms in poultry (chickens and broiler chickens).

Dosage

Administer orally with drinking water in a dose of 1-2 ml of the drug per 1 l of drinking water for 3-5 days.

For mycoplasmosis and ornithobacteriosis administer 2 ml per 1 l of drinking water for the first 3 days of life. It is recommended that the treatment is repeated in 20-22 days in a dose of 1-2 ml per 1 l of drinking water for 3 days.

Contraindications

Do not administer to poultry with hypersensitivity to the drug components, as well as hens, laying eggs for human consumption.

Do not administer in combination with antibiotics of the tetracycline group, chloramphenicol and lincomycin.

Do not administer to animals with impaired renal and/or hepatic function.

Precautions

The drug is not prescribed in sub-therapeutic doses.

If the mother solution is prepared, the drug shall be added in water, not vice versa. Medicated water shall be the only source of drinking water throughout the whole treatment period!

Poultry slaughter for meat is possible in 12 days following the last administration of the drug. Meat, obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of a veterinary physician.

Packaging

Glass or plastic vials of 10 and 1000 ml.

Storage

Store in a dry, dark place out of the reach of children at 5-30°С.

Shelf life

2 years.

24 hours after dissolution in drinking water.

For veterinary use only!