TIAKUR® 250

solution for injections

Description

Transparent brown liquid.

Composition

1 ml of the drug contains:

active ingredients: doxycycline hyclate – 150 mg; tiamulin (tiamulin hydrogen fumarate) – 100 mg;

excipients: 2-pyrrolidone, water for injections.

Pharmacological properties

Doxycycline is a broad-spectrum bactericidal antibiotic of the tetracycline group. It is effective against gram-positive and gram-negative baccteria (Staphylococcus spp., Streptococcus spp., Bac. аnthracis, Clostridium spp., Listeria spp., Actinomyces spp., Klebsiella spp., Shigella spp., Yersinia spp., Bordetella spp., Campylobacter spp., E. coli, Haemophilus spp., Pasteurella spp., Salmonella spp.), chlamydiae (Chlamydia spp.), mycoplasma (Mycoplasma spp.) and rickettsiae (Rickettsia spp.). It inhibits synthesis of microbial cell proteins, binding receptors of ribosomal 30S subunit in microorganisms. Doxycycline blocks attachment of aminoacyl tRNA to acceptor site, preventing attachment of new amino acids to peptide chain and preventing in such way synthesis of microbial proteins.

Tiamulin is a semi-synthetic derivative of the diterpene antibiotic, effective against gram-positive (Staphylococcus spp., Streptococcus spp., Clostridium spp., Corynebacterium spp., Erysipelothrix spp., Listeria spp.) and certain gram-negative microorganisms (Haemophilus influenzae, Pasteurella multocida, Actinobacillus pleuropneumoniae, Campylobacter spp.), spirochetes (Serpulina hyodysenteriae, S. innocens, S. pilosicoli, S. suis), as well as Lawsonia intracellularis. The mechanism of its antibacterial activity consists in inhibition of bacterial protein synthesis at the level of ribosomal 50S subunit.

Administration

Treatment of keratoconjuctivitis, colibacillosis, salmonellosis, pasteurellosis, staphilococcosis, gastroentherocolitis, mastitis, dysentery, atrophic rhinitis, enzootic pneumonia, actinobacillary pneumonia, haemophillosis, intestinal spirochetosis, necrotic enteritis in swine, cattle, sheep and goats. The drug is also effective in treatment of diseases of respiratory organs, urinary system, digestive tract, skin, musculoskeletal system, of post-surgical, wound and postpartum complications caused by doxycycline- and tiamulin-sensitive microorganisms.

Dosage

Administer intramuscularly for 2-3 days in the following doses:

cattle, sheep, goats, swine: 1-1.5 ml per 10 kg body weight.

Administer not more than 10 ml into a single site to adult cattle, not more than 2.5 ml – to calves, sheep and goats, not more than 5ml to swine. In case the required dose exceeds the acceptable dose – divide it and make injections to several sites.

Contraindications

Do not administer to animals:

- with hypersensitivity to tetracyclines and tiamulin;

- with kidney and liver disorders.

Do not administer ionophoric antibiotics (salinomycin, maduramycin, monensin, lasalocid, narasin) during 7 days prior to, and during 7 days following drug administration. Do not use Tiakur® 250 in combination with penicillins and cephalosporins.

Precautions

Animal slaughter for meat is allowed in 21 days following the last drug administration. Meat, obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of a veterinary physician. The drug is not prescribed in sub-therapeutic doses. Possible allergic reactions.

Packaging

Glass vials of 50 and 100 ml sealed with rubber stoppers and aluminum caps.

Storage

Store in a dry, dark place out of the reach of children at 5-30 °С.

Shelf life

2 years.

28 hours after initial opening, provided it is stored at 5-30°С in the original packaging.

For veterinary use only!