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GENTOVIT® 10%

GENTOVIT® 10%
Active substance —

water-soluble powder for oral administration

Description

Water-soluble white powder.

Composition

1 g of the drug contains:

active ingredient: gentamicin sulfate – 100 mg;

excipients: glucose.

water-soluble powder for oral administration

Description

Water-soluble white powder.

Composition

1 g of the drug contains:

active ingredient: gentamicin sulfate – 100 mg;

excipients: glucose.

Pharmacological properties

ATC vet QJ01 - antibacterials for systemic use. QJ01GB03 - gentamicin.

Gentamicin is an aminoglycoside antibiotic. It makes bactericidal effect upon gram-negative and, partially, upon gram-positive bacteria: Enterobacter aerogenes, E. coli, Klebsiella spp., Neisseria spp., Pasteurella multocida, Pseudomonas aeruginosa, Salmonella spp., Serratia marcescens, Shigella spp., Staphylococcus spp., окремі Streptococcus species і Proteus species, Serpulina (Treponema) hyodysenteriae, Mycoplasma spp., Corynebacterium spp., Bacillus spp., Clostridium spp., Lysteria monocitigenes. Gentamicin penetrates into cell by way of oxygen-dependent active transport and passive diffusion. Then it binds to protein receptors at the level of ribosomal 30S subunits and blocks formation of a complex, which includes mRNA, formylmethionine and tRNA. Consequently, there appears incorrect translation of tRNA, which results in formation of non-functional proteins.

It is poorly absorbed in blood and therefore acts only in organs of digestive system. Gentamicin does not demonstrate any toxic effect upon organisms of animals, does not cause any negative implications even in cases of major overdosing. Gentamicin is scarcely biotransformed in digestive tract and is excreted unchanged in feces.

Administration

Treatment of swine, calves (of up to 3 months of age), poultry (broilers, breeders, pullets) against diseases of digestive tract (colibacteriosis, salmonellosis, dysentery, campylobacteriosis) caused by gentamicin-sensitive microorganisms.

Dosage

Orally with drinking water or feed in the following doses:

  • swine: 5 g per 100 kg body weight (5 mg of gentamicin sulfate per 1 kg body weight) once a day (divide into 2 administrations). Duration of treatment –3-5 days;
  • poultry (broilers, brood hens, pullets): 5 g per 100 kg body weight (5 mg of gentamicin sulfate per 1 kg body weight) once a day. Duration of treatment – 5-7 days;
  • calves (under 3 months old): 5 g per 100 kg body weight (5 mg of gentamicin sulfate per 1 kg body weight) daily (divide into 2 administrations with interval of 12 hours). Duration of treatment –3-5 days;

Contraindications

Do not administer to animals with hypersensitivity to gentamicin. Do not prescribe the drug in combination with or subsequently to other oto- or nephrotoxic drugs (streptomycin, kanamycin, apramycin, neomycin, chloramphenicol) as well as diuretic and muscle relaxants. Do not administer to cattle with functionally developed proventriculi and hens laying eggs for human consumption. Do not administer to animals with kidney function disorders, ear and labyrinth disorders.

Precautions

Animal slaughter for meat is allowed as follows: calves, swine – in 10 days, broilers, brood hens, pullets – in 14 days following the last administration. Meat, obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of a veterinary physician.

If administered with feed, mix the drug with the feed thoroughly. It is recommended to mix it with 3-10 % of the total feed first, then mix the resulting mixture with the remaining feed.

Packaging

Polymer or glass jars of 500 and 1000 g, bags of film or foil materials of 50, 500 and 1000 g or paper bags of 5 and 25 kg.

Storage

Store in a dry, dark, damp-proof place out of reach of children at 0-30°С.

Shelf life

3 years.

24 hours after drug dissolution in water.

For veterinary use only!