METRILEK®

(suspension for intrauterine administration)

Description

Yellow suspension.

Composition

1 syringe tube (25 g) contains

active ingredients: cefquinome (equivalent to cefquinome sulfate) – 400 mg;

colistin sulfate – 95 mg;

Excipients: vaseline oil, vaseline.

Pharmacological properties                                                                       

АТС vet QG — antibacterials and antiseptics for intrauterine use. Antibacterials. QG51AA07 — Cefquinome.

Cefquinome is the fourth generation cephalosporin, , with a broad spectrum of antibacterial action against most gram-positive and gram-negative bacteria (Escherichia coli, Enterobacter spp., Staphylococcus aureus, Streptococcus spp., Clostridium spp., Actinobacillus spp., Citrobacter spp., Klebsiella spp., Pasteurella spp., Proteus spp., Salmonella spp., Serratia marcescens, Histophilus somni, Arcanobacterium pyogenes, Bacillus spp., Corynebacterium spp., Bacteroides spp., Fusobacterium spp., Prevotella spp. and Erysipelothrix rhusiopathiae, as well as against  β-lactamase producing strains. The drug bactericidal action mechanism is to inhibit the cell membrane synthesis of microorganisms.

Colistin is a polymyxins antibiotic with bactericidal effect on gram-negative microorganism (E.сolі, Salmonella spp., Pasteurella spp., Haemophіlus spp., Bordetella spp.). The mechanism of action of colistin consists in violation of integrity of cytoplasmic membrane in bacteria. Colistin interacts with phospholipids and penetrates inside, thus, it destroys the cell membrane structure. The bacterial membrane permeability changes right after contact with the drug. Apart from antibacterial effect, colistin binds phospholipid A and neutralizes toxic effect of bacterial endotoxin.

Administration

The drug is used for treatment of chronical and acute endometritides in cattle caused by cequinome-sensitive microorganisms.

Dosage

Administer contents of a single syringe tube intrauterinally with a single-use catheter. For this purpose connect the syringe tube to the catheter, take the cervix with hand, fix it through the rectum, carefully administer the catheter with the syringe through the cervix into the uterine cavity and eject the contents of the syringe tube with a plunger. If necessary, repeat the operation in 48 hours.

Contraindications

Administration of the drug to cows with hypersensitivity to cephalosporins and other β-lactam antibiotics, particularly – cefquinome, is prohibited.

Withdraw and conduct symptomatic therapy in case allergic reactions are observed.

Do not administer to pregnant animals.

Do not use the drug in combination with antibiotics of other groups.

Do not use in animals with severe renal and hepatic disorders.

Precautions

Side effect.

If the drug is administered in recommended doses, side effects do not appear.

In case of allergic reactions, the drug is discontinued and antihistamines are prescribed to the animal; if necessary, administer symptomatic treatment.

Special precautions for administration

The drug shall be used only after results of the microorganisms susceptibility test.

Excretion (withdrawal) period

Animal slaughter for meat is allowed in 2 days following the last administration of the drug. Milk consumption is allowed in 3 days following the last drug administration. Milk and meat, obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of a veterinary physician.

Packaging

Package of film materials with a polymer syringe tube (25 g), a catheter and 1 pair of rubber gloves.

Storage

Store in a dry, dark place out of the reach of children at 2-30 °С.

Shelf life

2 years.

For veterinary use only!