TIAMIX®

TIAMIX®

water-soluble powder for oral administration

Description

White powder.

Composition

1 g of the drug contains:

active ingredients: tiamulin (as hydrogen fumarate) – 225 mg;

lincomycin (as lincomycin hydrochloride) – 44 mg;

spectinomycin (spectinomycin sulfate) – 44 mg;

Excipient: dextrose.

Pharmacological properties

АТСvet: QJ01 - antibacterials for systemic use.

Tiamix® is a complex drug with a broad spectrum of antibacterial action. The combination of tiamulin, lincomycin and spectinomycin provides potentiated synergistic action on bacteria.

Tiamulin is a semi-synthetic derivative of the diterpene antibiotic pleuromutilin, effective against gram-positive (Staphylococcus spp., Streptococcus spp., Clostridium spp., Corynebacterium spp., Erysipelothrix spp., Listeria spp.) and certain gram-negative microorganisms (Haemophilus influenzae, Pasteurella multocida, Actinobacillus pleuropneumoniae, Campylobacter spp.), spirochetes (Serpulina hyodysenteriae, S. innocens, S. pilosicoli, S. suis), as well as Lawsonia intracellularis. The mechanism of its antibacterial activity consists in inhibition of bacterial protein synthesis at the level of ribosomal 50S subunit.

Lincomycin is a lincosamide antibiotic. It provides bacteriostatic or bactericidal action depending on concentration. It affects mostly gram-positive Staphylococcus spp., Streptococcus spp., Bacillus anthracis, Corynebacterium spp., gram-negative bacteria (Actinobacillus spp., Bordetella spp.) ccertain types of Nocardiа and Actinomyces. It is particularly effective against Serpulina hyodysenteriae and Mycoplasma spp. Lincomycin inhibits protein synthesis in microorganisms, binding ribosomal 50S subunits of bacterial cells.

Spectinomycin is a of tricyclic structure antibiotic of aminoglycosides. It is mostly effective against gram-negative microorganisms, particularly, E. coli, Pasteurella multocida, Salmonella spp., Clostridium spp., Erysipelothrix rhusiopathiae, Haemophilus spp., Vibrio spp., as well as gram-positive microorganisms and Mycoplasma spp. Its efficacy consists in inhibition of protein synthesis in microbial cell. By binding of ribosomal 30S subunit of microorganisms, it prevents elongation of polypeptide chain at translocation stage.

Tiamulin is quickly absorbed from digestive tract and penetrates into all swine organs and tissues, its maximum concentration is observed in 2 hours following administration. The antibiotic is primarily excreted in feces.

After oral administration, lincomycin is well absorbed from digestive tract (almost 60%) and distributed in organs and tissues, including the bone tissue. Lincomycin binds with proteins up to 50 %. Lincomycin concentration in serum reaches its maximum in 2 after administration. Its half-life makes 2.5-3 hours. Most of lincomycin and its metabolites are primarily excreted in urine and bile. Small amounts are excreted in feces.

Spectinomycin is poorly absorbed in digestive tract. In 24 hours following oral administration minor concentrations of the antibiotic are observed in kidneys, liver, lungs, muscles and fat tissue. Spectinomycin binding to proteins does not exceed 10%. Its concentration in serum reaches maximum in 4 hours. Spectinomycin is scarcely biotransformed in the body and is excreted unchanged in feces.

Administration

Treatment of lawsoniosis, enzootic pneumonia, actinobacillary pleuropneumonia, salmonellosis, dysentery, MMA (mastitis-metritis-agalactia) syndrome, eperythrozoonosis, necrotic enteritis, colibacillosis, mycoplasmosis and other diseases of digestive tract and breathing organs caused by tiamulin-, lincomycin- and spectinomycin-sensitive microorganisms in swine.

Dosage

Administer orally with feed individually or by group method in a dose of 0.5-1 kg of Tiamix® per 1 t of feed for 5-7 days or with drinking water in a dose of 0.5-1 kg of Tiamix® per 1000 l of drinking water for 5-7 days.

If administered with feed, mix the drug with the feed thoroughly. It is recommended to mix it with 3-10 % of the total feed first, then mix the resulting mixture with the remaining feed.

Medicated water shall be the only source of drinking water throughout the whole treatment period!

Contraindications

Do not administer to animals with hypersensitivity to tiamulin, lincomycin and spectinomycin.

Do not administer to rabbits, horses, cattle and laying hens.

Do not administer in pregnant and lactating animals.

Avoid administration of drugs containing monensin, maduramycin, narasin, lasalocid or salinomycin at least in 7 days prior to, during and in 7 days following administration of Tiamix® as this may cause deterioration in health condition or even death.

Precautions

Animal slaughter for meat is possible in 7 days following the last drug administration. Meat, obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of a veterinary physician.

Packaging

Packages made of film or foil materials of 100 and 200 g.

Paper bags of 25 kg.

Storage

Store in a dry, dark, place at 5-30 °С. Keep out of the reach of children.

Shelf life

2 years.

Shelf life after mixing with feed is 3 months.

Shelf life after dissolution in drinking water is 24 hours.

For veterinary use only!